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   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   Response - Clinical Study Report
   
   
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   Response - Researchers who provide a methodologically sound proposal.
   


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   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [shahinchembilaly@gmail.com].
   


6. For how long will this data be available start date provided 30-10-2025 and end date provided 30-10-2030?
   Response - Immediately following publication. No end date.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

INTRODUCTION:  Anaesthesia and Surgery can be stressful and traumatic experiences for children. They are especially vulnerable to long term Psychological Impairment resulting from stress. Incidence of pre-op anxiety is about 60-70 %in paediatric patients. This is associated with increased risks of negative effects as difficult induction, post-operative agitation and increased post-op pain.

Premedication are frequently administered in children to alleviate the stress and fear of treatmen well as to ease child-parent separation and promote a smooth induction of anaesthesia. Different kinds of medications have been used for pre-medication such as anticholinergic drugs, opioids, benzodiazepines and ketamine.

On literature search there are various studies on Oral midazolam, In those studies It alleviates an

and provide adequate sedation but has increased Risk of Respiratory Depression. Various studies

have been done for Oral premedication as alone or in combination, comparing Ketamine and

Midazolam, but very few studies compared the Oral Dexmedetomidine and Oral Ketamine.

Clonidine has significant analgesic properties because of its alpha-2-adrenergic agonism. One major downside of clonidine is longer duration of onset requiring administration 60 minutes before anaesthesia induction.

Ketamine is an easily administered parental anaesthetic that produces profound analgesia in sub- anaesthetic doses and lacks the cardiorespiratory depression seen with most other general anaesthetics. Ketamine is a phencyclidine derivative which acts on the n-methyl d-aspartate rece and causes central dissociation of the cerebral cortex while providing amnesia and analgesia and applied for premedication in different studies. Ketamine is most commonly used as premedicatio have been used to provide sedation and analgesia but may cause Nausea and Vomiting.

New Drugs such as Dexmedetomidine which is an Alpha-2-Agonist have emerged as an alternative for Premedication in Paediatric Anaesthesia having sedative, analgesic and anxiolytic property minimal respiratory depression and better Peri Operative Haemodynamic stability.

Dexmedetomidine and ketamine exhibit complementary pharmacological effects. Dexmedetomidine reduces cardiovascular responses and postoperative psychiatric adverse reactions attributed to