1. What data in particular will be shared?
   Response - All of the individual participant data collected during the trial, after de-identification.
   


2. What additional supporting information will be shared?
   Response - Clinical Study Report
   
   
3. Who will be able to view these files?
   Response - Researchers whose proposed use of the data has been approved by an independent review committee identified for this purpose.
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [tabasumfatim281@gmail.com].
   


6. For how long will this data be available start date provided 05-07-2025 and end date provided 07-07-2050?
   Response - Immediately following publication. No end date.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - nil

WaramTajäwéf al-AnfMuzmin (Chronic Sinusitis) is the chronic inflammation of para nasal sinuses which affects all people worldwide.Symptoms and signs of NazlaBäridMuzmin have been described in details in of Unani literature which closely resemble the symptoms of chronic sinusitis, although IltihäbTajäwéf al-Anf or WaramTajäwéf al-Anf (Sinusitis) has not been mentioned as a disease in literature of Unani Medicine.^(1,2,3,4) Therefore, NazlaBäridMuzmin has been considered as WaramTajäwéf al-AnfMuzmin (Chronic Sinusitis). WaramTajäwéf al-AnfMuzminis called chronic sinusitis in modern medicine, which is a chronic inflammatory condition of upper respiratory tract involving the paranasal sinuses. It is usually followed by coryza and cold or sometimes is caused by dental infection, deeply seated in upper jaw. Most of the times, the maxillary sinuses are involved. However, it may also affect other sinuses on one or both sides.^(5,6,7)Chronic sinusitis is characterized by symptoms of sinusinflammation lasting more than 12 weeks. This illness is mostcommonly associated with either bacteria or fungi, and clinicalcure in most cases is very difficult.28 In this stage, the damageto the mucus membrane occurs which leads to the impairmentof the ciliary activity and thickening of mucus membrane. Thiscondition may progress until the sinus is filled with polypi andpus, which is discharged at frequent intervals into the nose.Symptoms are varied and complaint may be of frequent colds,or an unpleasant taste or a bad smell in the nose. The discharge is frequently foul. As the condition settles into the chronic stage, pain and tenderness disappear The treatment of choice for chronic sinusitis in conventional medicine is nasal or oral corticosteroids, antibiotics, nasal sprays, decongestants. The drugs are associated with various side effects like nose bleeds, stinging sensation in the throat and nose, in rare cases nasal perforation can also occur due to use of nasal corticosteroids. Therefore a polyherbal formulation comprising of Pudina (Menthaspicata L.), Ajwain(PtychotisAjowan), Ustukhudus (Prunella Vulgaris), Marzanjosh (OriganumMajorana) and Guletesu (Butea Frondosa) will be given as inhalation or Shamoom to the patients and efficacy will be tested.

Study design: Open observational study.

Sample size: 20 patients.

Intervention.

Test drugs:Pudina, Ajwain, Ustukhuddus, Marzanjosh, GuleTesu.

Method of Prepration:

Dosage: 5 gm of each drug taken in 200ml of water and boiled and shamoom or inhalation taken daily at bed time for ten minutes.

Route of Administration: Inhalation

Duration   of Protocol: 45 days with follow up as ( 15^th, 30^th,45^th)

Duration of Study: 2 years

Procedure of study:

Enrolled cases of Sinusitis will be taken, after obtaining a written informed consent. The patients will be treated with test drugs and pre and post treatment subjective and objective findings (effects) will be compared and its significance will be evaluated through a suitable statistical test.