The clinical study titled “Efficacy of Murivenna Bandage and Agnikarma in the Management of Snayugata Vata (Carpal Tunnel Syndrome)” was an open-labelled, randomized comparative trial conducted on 30 patients diagnosed with Carpal Tunnel Syndrome (CTS). Participants were divided into two groups: Group A received Murivenna bandaging once weekly for four weeks, and Group B underwent Agnikarma at the tender points of the wrist for the same duration. The assessment included both subjective parameters (pain, Tinel’s sign, Phalen’s test, carpal compression test, and Boston CTS Questionnaire) and objective measures (nerve conduction study and wrist range of motion). Demographic analysis revealed a predominance of females (79%), mostly postmenopausal housewives from the middle socioeconomic class, with the majority aged between 51–60 years. The right hand was more frequently affected, and most patients had symptoms for less than six months with gradual onset.

Both Murivenna bandage and Agnikarma showed highly significant improvements (P < 0.001) in all subjective and objective parameters, including pain relief, CTS test outcomes, nerve conduction velocity, and wrist mobility. Comparative analysis between the two groups demonstrated no statistically significant difference in most parameters, indicating that both therapies were equally effective. However, the Functional Severity Scale of the Boston Questionnaire (P = 0.018) and palmar flexion range of motion (P = 0.023) showed significant differences, suggesting slightly superior functional improvement with Agnikarma. Both interventions provided relief from pain, tingling, and numbness, and improved wrist movements. Murivenna bandage was more effective in acute inflammatory and traumatic conditions, whereas Agnikarma produced better outcomes in chronic pain cases. Seasonal variation was also noted—Murivenna was more effective during the hot season, while Agnikarma showed better results in the cold season. Both treatments were cost-effective, minimally invasive, non-pharmacological, and suitable for outpatient management, with no adverse effects reported during the study or follow-up. Hence, the null hypothesis was accepted, confirming that Murivenna bandage and Agnikarma are equally effective in the symptomatic management of Snayugata Vata (Carpal Tunnel Syndrome).