As per data released in May 2022 by Indian Society of Organ Transplants, patients waiting for various organs transplant in India are approximately 3.17 lakhs. Approximately 55% of these patients are waiting for kidney transplant. However only less than 10% patients requiring kidney transplant end up receiving a kidney. A large majority of organ donations in India are from live donors. Cadaver donations represent only about  5% of all donations. As per data for the year 2021 from National Crime Records Bureau, the fatalities attributed to road traffic accident in India were approximately 1.55 lakhs. The cause was head injury in 40-50% of cases. About 70% of the accidents involved young adults.

      It is estimated that if 5-10% of all brain-dead patients are considered for organ harvesting, there would be no requirement for a living person to donate organs. However the donation of organs from brain-dead patients is highly under-utilized due to lack of awareness, religious beliefs and challenges in identifying potential brain-dead organ donors and managing them prior to organs retrieval.

     To boost the number of potential donors and increase cadaver (post brain death) organ donations, the government of Maharashtra has passed a resolution making it mandatory for authorized medical practioners to certify the patients who have reached the brain dead stage as brain-dead without wasting time. The government resolution underlines the responsibilities of hospitals registered under Transplantation of Human Organs (THO) Act 1994 that are authorized transplant centers. As per Indian law, two apnea tests are required to be done at minimum of 6 hours apart in a patient having no brainstem reflexes to declare him/her as brain-dead. If apnea test is inconclusive or could not be done, various ancillary tests may be performed like electroencephalography, trans-cranial doppler, coronary angiography, etc. However due to various factors, some of these potential donors do not end up becoming actual donors due to factors mentioned above.

     The present prospective case series aims at assessing the challenges that prevent successful conversion of potential brain-dead organ donors to actual organ donors. This study will be conducted at a military organ transplant center in India.