One’s personality and general identity are both reflected in their hair. In women, hair is femininity and adornment provided by nature. A full head is often associated with youth and vitality in men. It serves as the pinnacle of one’s personality and serves as the center of attention. As a result, everyone is more aware of the issue and looking for better hair growth treatment. Everyone is aware of the growing social problems of hair loss, pattern baldness, hair thinning, and other related difficulties, but many choose not to discuss them. Consequently, all genders have strong feelings about hair. Pollution, poor food and exercise habits, stress and tension, increased industrialization, and urbanization, as well as other inherent environmental and hereditary causes, all contribute to the rising rate of obesity in today’s fast-paced society. Any type of hair loss can affect one’s physical appearance and psychological well-being.

In Ayurveda, hair loss problem has been described as khalitya. Acharya Vagabhatta has described khalitya under the heading of Shiro-Kapalagata rogas.Acharya Vagabhatta differentiated Indralupta and Khalati by saying that in Khalati loss of hair occurs gradually than Indralupta, while pathology is common in both the diseases of hair. Acharya Charaka describes that Tejas combining with Vata adi dosha reaches the Shira kapala and causes hair fall by dahana of Romakupa Acharya Sushruta also mentioned the same Nidana and Samprapti as Charaka but under Kshudra roga.5 In present era life is very fast & competitive. So, people take junk foods miscombination of food i.e Abhishyandhi & Akalabhojana, over eating i.e Adhyashana, spicy and oily food i.e ushna, Tikshna Ahara etc. Khalithya can be categorized as Male pattern baldness. Androgenetic alopecia is a generic form of hair loss in both men and women. In men, it is also known as male pattern baldness, and in women, it is also known as female pattern hair loss. In

men, hair is lost in a well-defined pattern, beginning above both temples. Over time, the hairline moves back (recedes) to form a characteristic "M" shape. (“Androgenetic alopecia: MedlinePlus Genetics”) Hair also thins at the top of the head (vertex or crown), often progressing to partial or complete baldness. The pattern of hair loss in women differs from male-pattern baldness. In women, the hair becomes thinner at the top of the head, and the middle part widens. The hairline does not typically recede. Androgenetic alopecia in women rarely leads to total baldness. Androgenetic alopecia in men has been associated with several other medical conditions, including coronary heart disease and enlargement of the prostate. Additionally, prostate cancer, disorders of insulin resistance (such as diabetes and obesity), and high blood pressure (hypertension) have been related to androgenetic alopecia. 2 In women, this form of hair loss is associated with an increased risk of polycystic ovary syndrome (PCOS). Alopecia areata is an immune-mediated condition leading to non-scarring alopecia of the scalp and other hair-bearing areas of the body. It affects up to 2% of the global population. It can affect all ages, but the prevalence appears higher in children compared to adults (1.92%, 1.47%). A greater incidence has been reported in females than males, especially in patients with late-onset disease, defined as age greater than 50 years.3 PCOS is characterized by a hormonal imbalance that can lead to irregular menstruation, acne, excess hair elsewhere on the body (hirsutism), and weight gain. Ayurveda claims that vitiated pitta and vitiated vata work together to induce hair loss from the scalp. The orifices of the hair follicles are then blocked by vitiated Rakta and kapha, which inhibits the formation of new hair. Thus, the key internal causal components of khalithya are Rakta dushya (one of the areas in the body where the disease arises) and the vata, pitta, and kapha dosha (three factors responsible for all physiological processes inside the body. There are currently many treatment modalities are available in modern medicine: surgical

restoration and non-surgical restoration of hair like Intralesional corticosteroids, topical corticosteroids, minoxidil, anthralin, topical immunotherapy, prostaglandin analogues, topical retinoids, bexarotene 3 among all even though there is marked improvement from current treatments for this illness, but these are not fully curative or preventative. The new treatment modalities like PRP (platelet rich plasma) therapy and GFC (growth factor concentrate) are having marked improvement when it is done with other supporting oral medications like finasteride, biotin supplement. But after stopping the oral medications and topical solutions again the patient will see the hair fall and thinning so it has become dependent therapy so to overcome that There is a need for treatment that eases hair growth. Plasma has various Growth factors which are stored in blood platelets, which help regenerate and repair the tissues and stem cell proliferation, migration, and differentiation. As each growth factor plays a different role in the regrowth of the hair follicle like Platelet-derived Growth Factor (PDGF): PDGF helps increase hair growth and works as a stimulator for Vascularization and Angiogenesis. It also helps in the mitogenesis of mesenchymal stem cells and endothelial cells and proliferation and chemotaxis of fibroblasts. Vascular Endothelial Growth Factor (VEGF): VEGF is expressed in DP cells in the anagen phase of hair and regulates perifollicular angiogenesis in hair. It also increases perifollicular vessel size during the anagen growth phase to make the process smooth. Epidermal Growth Factor (EGF): EGF promotes hair cell proliferation and regeneration and stimulates mitogenesis of mesenchymal and epithelial cells. Additionally, it also co- stimulates angiogenesis. Insulin-like Growth Factor-1 (IGF-1): IGF-1 keeps HF growth, increases overall hair growth, and works as an angiogenesis stimulator.5 Hence the integrated approach by selecting GFC therapy in addition with ayurvedic Shamanoushadhis we can treat the cases of khalithya effectively. The drugs selected in the study are the drugs which are quoted in Bhavaprakasha6 as keshya these selected drugs will be used to prepare a Kesha Taila and orally.