Breast cancer is one the most common cancer occurring in the world and in India. Breast cancer treatment includes chemotherapy, surgery and radiotherapy. In some stages of breast cancer, size of tumor is large without metastasis to other sites of body. In this stage of tumor, chemotherapy (NACT- Neo Adjuvant Chemo Therapy) is given before the surgery to decrease size of tumor so that less extensive surgery can be performed. In this proposed study, we are trying to study response to this chemotherapy (NACT) using elastography. Elastography measures hardness (stiffness) of tissue. Elastography is performed along with sonography of breast using the same machine where additional measurements (of stiffness of tissue) are taken along with routine sonographic evaluation.  Our hypothesis here is, as the patient is on chemotherapy, the hardness of the tissue should decrease and so should the values on elastography and if this decrease in elastography values correlates with final outcome of patient on histopathology report. 

For the study the patient will have to undergo additional ultrasonographic evaluation (intervention) post 2 cycles of chemotherapy, the values of which which will be compared to baseline ultrasonography parameters (Performed as standard of care in TMH). We will finally evaluate if elastography values can predict responders vs non responders to NACT.

The patient will not be charged for this intervention. If a certain patient does not come or denies this additional investigation or denies to be a part of the study at any given time, that patient will not be included in the study and standard of care will not be affected.