Despite the emergence of new airway devices in the recent years, rigid laryngoscopy and tracheal intubation still remains the gold standard in airway management. Tracheal intubation is a commonly used technique in general anaesthesia, but it can cause a few side effects, including sore throat and hoarseness. These symptoms, known as postoperative sore throat (POST) which occurs in 21–65% of patients receiving general anaesthesia (GA) with tracheal intubation. POST had been rated by patients as the eighth most adverse effect in the postoperative period. Although POST is a minor side effect and is self-limiting, it causes a great deal of patient dissatisfaction. So prophylactic management of POST is recommended to improve the quality of post- anaesthesia care, though the symptoms resolve spontaneously without any treatment in most of the cases.

A previously studies had shown comparison between magnesium and ketamine gargle efficacy in decreasing the incidence of POST, but nebulization is superior to gargle. In this study we compare the effect of Nebulized Ketamine and Nebulized Magnesium sulphate to prevent Post operative sore throat.

This study will be prospective, double blinded randomized clinical trial to compare the effects of Nebulized ketamine versus Nebulized Magnesium sulfate for the Prevention of Post operative sore throat. A total of 142 patients of either sex will be selected for the study and divided into 2 groups Group K will receive Nebulization of ketamine 50mg in 5ml Normal saline and Group M will receive Nebulization of Magnesium sulphate 250mg in 5ml Normal saline. The patients will be looked for Post operative sore throat and if present, will be scored as 0 = No sore throat, 1 = Mild sore throat, 2 = Moderate sore throat, 3 = Severe sore throat. The data will be entered in SPSS version 26.0 and analysed using ANOVA test or Pearson Chisquare test as where appropriate.