This is Retrospective Observational study. in which Role of disorganization of inner vs outer retinal layers in predicting the response to ANTI-VEGF treatment in diabetic macular edema will be studied.

·         Permission to access the records in the medical records department will be taken from The Medical Superintendent.

·         Description of process :Step 1- to obtain IEC and CTRI clearance

·         Step 2- We will retrospectively review the medical records of patients who had who met the inclusion criteria will be selected from the medical records and will be included in the study .And patients falling under exclusion criteria will be xcluded

·          Step 3- for the selected patients the baseline OCT,visual acuity and 1 month post 3 rd ANTI-VEFG injection visual acuity and OCT macula data will be collected from the medical records .In addition to these other parameters like HBA1C, serum creatinine values will also be collected from medical records.

·         Outcome measures: Outcome measures include effect of retinal outer and inner layers morphology on visual acuity and central retinal thickness.

·         Potential risks and benefits: There is less than minimal risk for patient as it was purely an retrospective study in which we collect data from medical redords and we don’t alter or introduce any other tests other than treatment plan. In this study role of disorganisation of retinal inner vs outer layers of retina in predicting response to anti-VEGF treatment in DME will be studied which might aid in predicting the disease prognosis and disease management.

·         We will only review the records from the medical records department who fit the inclusion criteria and no active intervention will be done.