Tooth extraction is a standard dental procedure used to manage various dental conditions. (Buchwald) The healing process after extraction is a complex series of bone cell migrations and maturation, leading to selective bone resorption and formation. This process reduces a dimensional alveolar ridge in horizontal and vertical directions. Replacing missing teeth, especially with implants, becomes more challenging due to the loss of necessary bone volume for successful implant placement. This post-extraction bone loss often requires bone grafting procedures to restore function and aesthetics reliably. Our study aims to shed light on this complex process and potentially offer a solution to the associated challenges.

Various procedures prevent post-extraction bone loss and ensure predictable implant placements, including socket preservation with grafts (biomaterials) and immediate or early implant placements. While clinicians have a range of graft materials to choose from, some bone graft materials require longer healing time to achieve even a small amount of new bone incorporation into the graft site (Norton and Wilson, 2002).

Platelet-rich fibrin (PRF) is a material derived from autologous blood preparation and is known for its exceptional ability to promote bone healing and regeneration. It acts as a scaffold and filler material due to its 3-dimensional structure, attracting and enriching various types of cells to migrate and proliferate here and accommodate them for extended periods. It contains multiple growth factors that can affect the expression of osteogenic genes, promote the metastasis and differentiation of mesenchymal stem cells, inhibit the generation of osteoclasts, and promote angiogenesis to achieve bone regeneration. Our study aims to harness this potential of PRF, adding it into the extraction socket and evaluating soft and hard tissue healing.