Background –

Managing pain following spinal surgery is still a clinical challenge. For patients to remain comfortable and heal properly, post-operative pain management must be effective. Research has been done on epidural analgesia as a possible treatment option for post-operative pain following spine procedures. Given the ability to enhance hemodynamic stability and pain reduction, α2 adrenergic agonists are proposed as adjuvants to local anaesthetics in this regard.

Objectives –

The objective of this protocol is to contrast and assess the efficiency of two different α2 adrenergic agonists, dexmedetomidine and clonidine, given in conjunction with epidural ropivacaine as adjuvants for post-operative analgesia following spine procedures. The primary objective is to evaluate the effectiveness of these analgesics in relieving pain; other goals include comparing the amount of opioids used, monitoring hemodynamic parameters, and adverse effects, and improving patient satisfaction.

Methods –

The research will be done as a prospective, double-blinded, randomised clinical trial. Random assignment will be used to allocate patients to one of two groups: either the Ropivacaine with Clonidine or the Ropivacaine with Dexmedetomidine group. A number of variables will be observed and compared between the two groups, including patient satisfaction, hemodynamic measurements, opioid use, pain scores, and side effects.

Conclusion –

The necessity of efficient post-operative pain control in spinal operations makes this study significant. This study intends to provide important insights into enhancing patient comfort and safety by contrasting the use of clonidine and dexmedetomidine with epidural ropivacaine. The findings of this study may influence clinical practice and result in more individualised pain management plans for individuals undergoing spine surgery while limiting the negative effects of opioids.