Various methods of administering dexamethasone in third molar surgery have been proposed. Intravenous (IV) injection requires additional clinical expertise, and administering IV dexamethasone in conscious patients may lead to transient perineal irritation (itching, burning, or squeezing sensation) in some individuals. Additionally, a single IV injection of dexamethasone can spread widely throughout the body, potentially resulting in less than optimal effectiveness at the injury site.

The sublingual route has advantage of not causing additional postoperative pain for patients when administered following common dental interventions like the inferior alveolar nerve block, lingual nerve block and long buccal nerve block typically performed in mandibular third molar procedures. This method is straightforward and easily manageable for dentists.

In present study, the effectiveness of dexamethasone administered via sublingual versus intravenous routes will be assessed, the outcome of this study will help the dental surgeons to choose the appropriate route of administration of dexamethasone.

Under strict aseptic conditions, patients will be prepared for the surgical procedure. A classical inferior alveolar nerve block, along with lingual and long buccal nerve block will be administered. After 5 minutes, patients in Group A will receive 8 mg dexamethasone intravenously injected into either the median cubital or radial vein, whereas, patients in Group B will receive 8 mg injection dexamethasone into sublingual space. Time taken to administer dexamethasone through both the routes will be noted using timer. Utilizing a standard Ward’s incision, access will be gained, and the tooth will be extracted after necessary bone cutting and tooth splitting, ensuring minimal tissue trauma.  Post-extraction, the socket will be thoroughly irrigated with a 5% povidone-iodine solution diluted with equal proportion of normal saline. The flap will then be sutured back using two interrupted sutures of 3-0 BBS (Black Braided Silk). Follow-up appointments will be scheduled for all patients on first,second,third and seventh postoperative days. Suture removal will be carried out on the seventh postoperative day if the healing is assessed to be satisfactory.