The study will aim to compare the efficacy of topical ozonated olive oil and topical triamcinolone acetonide in managing recurrent aphthous stomatitis (RAS). RAS, characterized by painful oral ulcers, lacks a specific cure, with treatments focused on symptom management. Corticosteroids, including triamcinolone acetonide, will be commonly used for RAS treatment due to their anti-inflammatory properties. Conversely, ozone therapy, aimed at enhancing oxygen levels and harnessing antimicrobial effects, will be gaining attention.

The sample size calculation will determine a total of 60 participants, divided equally into two groups: one treated with topical ozonated olive oil and the other with topical triamcinolone acetonide. The study will include individuals aged 16 years and above, without systemic diseases or medication for oral ulcers.

Data collection will involve assessing pain intensity using a visual analogue scale (VAS) and measuring ulcer size with a graded periodontal probe. Treatment application will occur four to five times daily until complete ulcer healing, with evaluations on the second, fourth, and sixth days.

Statistical analysis, to be conducted using SPSS version 23, will include descriptive statistics, frequency distribution, and independent sample t-tests for intergroup comparisons (p < 0.05).

The outcomes will focus on pain relief, ulcer size reduction, and healing duration. Pain intensity will be measured on a scale of 0-10, while ulcer size will be recorded at different time intervals.

In conclusion, the study will seek to provide insights into the comparative effectiveness of topical ozonated olive oil and topical triamcinolone acetonide in managing RAS. Results will contribute to understanding optimal treatment strategies for this prevalent oral condition, potentially improving patient comfort and quality of life.