Residual ridge resorption (RRR), which occurs after tooth extraction, is a chronic, continuous, irreversible, and accumulative type of bone resorption.  Because of the continued resorption of alveolar bone, this causes multiple cosmetic and functional challenges in individuals who have missing teeth.  Consequently, in order to maintain the existing alveolar ridge, a great deal of research has been conducted on methods to stop the loss of alveolar bone or encourage the development of new bone. In view of this, a study will be conducted to assess and compare the effectiveness of PRF and Simvastatin in terms of their ability to promote bone regeneration and their ability to repair wounds in the extraction socket of mandibular molars.

Objectives

• To evaluate the effects of Simvastatin-impregnated gel foam on regeneration of bone and wound healing in patients undergoing mandibular molar extractions against those using PRF.

Methods

Procedure will be performed in patients undergoing extraction of mandibular molars. Patients will be divided in 2 groups. Immediately after the extraction, In Group 1, extraction sockets will receive Gel Foam as a carrier for the medication Simvastatin (10 mg, crushed and dispersed into normal saline); in Group 2, PRF will be grafted.

 Expected results

For individuals having their mandibular molars extracted, gel foams infused with simvastatin will promote improved wound healing and bone regeneration.

 Conclusion

It is hypothesized that Simvastatin impregnated gel foam placed might give better results.In patients having mandibular molar extraction, if Simvastatin Impregnated Gel foam is shown to be superior to PRF in regard to regeneration of bones and wound healing, it will overcome the disadvantage related to PRF i.e, collection of blood via Phlebotomy, cost of Centrifuge machine used to make PRF.