1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   Response - Informed Consent Form
   Response - Clinical Study Report
   
   
3. Who will be able to view these files?
   Response - Anyone
   


4. For what types of analyses will this data be available?
   Response - Any purpose.
   


5. By what mechanism will data be made available?
   Response (Others) -  will be published at journal


6. For how long will this data be available start date provided 26-06-2024 and end date provided 26-04-2025?
   Response - Immediately following publication. No end date.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

     Malignant biliary obstruction is an enfeebling condition that can causes pain, jaundice, pruritus, anorexia, metabolic encephalopathy and later can cause mortality. For its definitive management biliary decompression is performed via endoscopic, percutaneous, and surgical approaches. Minimally invasive (Percutaneous) techniques are now choice of care, preferable to conventional surgical bypass because of lower intraprocedural morbidity and lower overall hospital stay.

Percutaneous biliary drains are often painful due to measures during PTBD provoke intense pain sensations of very short duration such as mechanical stretching of biliary tree, peritoneal transgressions or balloon dilatation procedures and caustic nature of bile which may inflame the skin near the insertion site, Therefore, another measures to be taken care about is the optimal pain management of the patients undergoing percutaneous biliary intervention.

Another point of concern is the development of tolerance to opioid analgesics which is a major barrier to clinical opioid therapy. Opioid tolerance is a pharmacological phenomenon caused by repeated opioid exposure leads to receptor resistance that causes decreased analgesic effects. hence the effective means to ease the intractable visceral pain associated with abdominal malignancy is to interrupt the nociceptive impulses at the level of the celiac plexus or splanchnic nerves.

So our aim of the study is to assess the Analgesic efficacy of celiac plexus neurolysis in patients undergoing percutaneous biliary intervention with upper abdominal malignancies.

Firstly the patient with upper GI malignancy with pain score equal to or more than 7 with biliary dilatation will be taken for study with no exclusion criteria should be met. After pre-operative assessment, proper written consent the patient will be divided into 2 groups, 1^st group will receive Celiac plexus neurolysis for the management of pain followed by percutaneous biliary intervention while the 2^nd group will be directed to percutaneous biliary intervention with support of intravenous analgesia inter-operatively.

Our objective is to asses the peri-operative and post-operative (1 day) pain with the help of NRS (numerical response scale) in both groups.

Followed by comparison of mean NRS score in both groups using required software (SPSS) and calculate the test of significance.