1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Statistical Analysis Plan
   Response - Clinical Study Report
   
   
3. Who will be able to view these files?
   Response - Researchers whose proposed use of the data has been approved by an independent review committee identified for this purpose.
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [alfaiz3499qureshi@gmail.com].
   


6. For how long will this data be available start date provided 01-06-2024 and end date provided 01-06-2030?
   Response - Immediately following publication. No end date.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

o   Nocturnal Enuresis is very embaressing for any sufferers and in children as the age advances it may produce a deep and very shameful impact to the patient.

o   Nocturnal enuresis in children is the 2nd most common disorder after allergic disease.^[1] The worldwide prevalence of enuresis among children aged 6-12 years is 1.4%- 28%. The prevalence in India is 7.61%-16.3%. The prevalence is highest in children aged 5-8 years & lowest in children aged 11-12 years. Nocturnal enuresis has been reported in 18.4% of children with sleep problem.^[2]

o   In conventional system of medicine, they usually give hormone like medication (desmopressin) & the anti-depressant imipramine. Disadvantage of medication is that it usually only works temporarily while you take it. There is also side effects of these medication found in children such as headache, nausea, vomiting & dizziness.^[3]

o   As the cause for nocturnal enuresis is moreover developemental or improper training or psychogenic like

ü  Stressful life events such as family conflicts, moving to a new place, starting a new school or parental divorce can trigger bedwetting in some children. Anxiety about these situations can lead to disrupted sleep patterns and increased bladder activity during sleep.

ü  Emotional disturbances such as fear, insecurity or unresolved emotional conflicts can manifest as bedwetting. Children who feel anxious, insecure, or have low self-esteem may be more prone to bedwetting.

ü  Excessive pressure from parents to stay dry at night or punitive responses to bedwetting can exacerbate the problem. This pressure can increase the child’s anxiety and worsen their ability to control their bladder at night.

other modes of treatment can’t offer much in addressing the Nocturnal Enuresis.

o   Homeopathy has surged in popularity within the medical community, offering efficient solutions to completely eradicate diseases from the system, ensuring comfort. Embracing a holistic approach, homoeopathy focuses on identifying and addressing the underlying causes of ailments. It provides a dependable and ethical mode of treatment. Wellness, as the integration of body, mind, and spirit, underscores the understanding that our actions, thoughts, emotions, and beliefs profoundly impact our well-being. Health, therefore, encompasses the entirety of the individual rather than focusing solely on isolated parts or organs. Homoeopathy, founded on this principle, constitutes a comprehensive system of medicine that considers the entirety of an individual’s being; facilitating the removal of root causes underlying diseases. By addressing the cause, the symptoms naturally diminish.

o   And thus, homoeopathic remedies have shown effectiveness in alleviating enuresis and reducing its likelihood of recurrence, all without the risk of side effects which is commonly associated with allopathic treatment.

RESEARCH QUESTION:

o   Whether the patients suffering from Nocturnal Enuresis will get beneficial relief after prescribing Homoeopathic Medicines?

HYPOTHESIS:

o   Null Hypothesis – There will be no improvement after prescribing homoeopathic medicines