TITLE  -

 â€œCLINICAL STUDY TO EVALUATE THE EFFICACY OF PATHYADI KWATH ALONG WITH  RASNADI  TAILA  NASYA AS DESCRIBED IN AYURVEDA SAMHITAS IN THE MANAGEMENT OF ARDHAVABHEDAKA W.S.R. TO MIGRAINE”.

AIMS & OBJECTIVE - 

·       To evaluate the efficacy of Pathyadi kwath and Rasnadi  Taila Nasya in the management of Ardhavabhedaka ( Migraine).

To assess the effect of trial drugs in improving the signs, symptoms as per assessment criteria and HIT-6 Test.

INTRODUCTION :-

Our ancient sages have described three vital organs and have given prime importance to head i.e., Shirah, as the existence of body depends upon the vital organ.Shirah is that part of the body where life along with sense faculties resides.

Almost all our ancient Acharayas have mentioned about the Shiro-roga of which Shirah-shoola as the main symptom and also they have taken Shirah-shoola as the synonym of Shiro-roga. Ardhavabhedaka is a Shiroroga mentioned in various texts of Ayurveda. Some Acharyas has been classified as Vataja, Vatakaphaja and Tridoshajaroga.

Ardhavabhedaka etiology and symptoms are most appropriately related to migraine hence it can be co-related with Migraine headache of Modern medicine.

Migraine being a primary headache, affects one in seven globally and  is the second most common  type of neurovascular headaches. It is the third most common disease in the world characterized by recurrent headaches that are moderate to severe and seventh highest specific cause of disability worldwide (GBD 2012).  â€œTypically in Migraine, the headaches affect one half of the head, are pulsating in nature, and last from 4 to 72 hours. Associated symptoms may include nausea, vomiting, and sensitivity to light, sound, or smell.”

NEED OF THE STUDY:- 

Ø  In Present Scenario the incidence of migraine is increasing day by day. It affects the personal, social, and economic life of a person.

Ø   Person wants instant relief in migraine.

Ø  In Modern Medical Science, there is only symptomatic treatment of migraine, for example NSAIDS group, Beta blocker, anti-seizure, antidepressant, calcium channel blocker etc. and long-term use of these drugs can lead to stomach ulcers, hepatotoxic, renal problem, decreased heart function, asthma and many more.

Ø   So, to get out of these problems we need Alternative approach of management.

Study Design :-

Study Type                 :          Interventional
Purpose                        :          Treatment
Masking                      :          Open Labelled, Clinical trial
Direction                     :          Prospective
End point                     :          Efficacy
No. of Groups             :          Single Group
Sample size                 :          30 Patients  

Probable Mode of Action of Drug :-

Ø  Pathyadi Kwath is tikta kashaya rasa pradhana, having madhur vipaka and ushna veerya with laghu & ruksha guna predominance.

Ø  Practically most of the patients with migraine are seen having hyperacidity, history of consumption of street food, spicy food, night out, stressful lifestyle these are described as pitta prakopaka hetus in Ayurveda, which are responsible for nausea, vomiting, vertigo.

Ø  So considering pitta predominance in Ardhavabhedaka tikta kashaya and madhur vipaka of Pathyadi kwath will be best pittashamaka dravya.

Ø  Katu and tikta rasa of pathyadi kwath have deepana, pachana karma that helps to improve metabolism by the property of Amapachana.

Ø  Ushna veerya of pathyadi kawth act as stroto shodhaka and kleda shoshaka; eliminate morbid doshas accumulated in the body.

Ø  Though the percentage of ushna veerya dravya are 57% it is not that high to cause pitta prakopa rather it balances associated kaphadosh in Ardhavabhedaka.

Ø  In addition, laghu and ruksha guna act as kleda shoshaka, mala of kapha dosh.

Ø  Nasya aushadhi reaches to brain via nasal route and acts on higher centers of  brain  controlling  different  neurological,  endocrinal  and circulatory  functions  and  thus  showing  local  as  well  as systemic   effects.

 All we can say pathaydi kwath and nasya can break the samprapti of Ardhavebhedaka.

TREATMENT  REGIMEN :-

 Duration â€“ 8 weeks

Follow up – 6 MONTHS