Chronic kidney disease (CKD) is a condition that leads to a gradual decline in kidney function. It’s a major global health concern. Dapagliflozin is a Sodium-glucose co-transporter 2 inhibitor (SGLT2i) known for reducing glycated hemoglobin (HbA1c). The results from the Dapagliflozin-Chronic Kidney Disease (DAPA-CKD) trial affirm that the positive impacts of SGLT2 inhibitors on kidneys are not solely tied to glucose reduction. As a result, this drug class is now deemed fundamental therapy for CKD. The utilisation of SGLT2 inhibitors has been limited, and those at the highest risk are less likely to be prescribed them. The reasons for the underuse of SGLT2 inhibitors in routine practice are complex and not fully understood. Medication knowledge can be defined as the awareness of the drug name, purpose, administration schedule, adverse effects or side effects, and special administration instructions. Providing patients with informative leaflets can enhance their comprehension and awareness of chronic kidney disease. Adverse Drug Reaction (ADR) is characterized as an unintended and noxious response to a drug, occurring at doses typically used in humans for prophylaxis, diagnosis, treatment of a disease, or the modification of physiological function. Our study is conducted in a tertiary care clinic aims to assess the usage rate of dapagliflozin and factors affecting its usage among patients with CKD, assess the basic medication knowledge of CKD patients and see the importance of developing and evaluating a patient information leaflet (PIL) for CKD patients. Identifying and reporting any Adverse Drug Reactions (ADR) that occur after taking Dapagliflozin medication. Data collection involves data collection forms and questionnaires and interviewing the doctor. The collected data will be analysed using descriptive statistical tools (MS Excel, SPSS) such as frequency, percentage, mean, standard deviation, chi-square test, and independent t-test. The study will utilize the WHO UMC Causality Assessment Scale to evaluate and assess adverse drug reactions (ADRs) in our research. The study’s implications are significant, providing insights into rate of utilisation of dapagliflozin amongst CKD patients, the importance of evaluating and developing a PIL for CKD patients, and identifying and reporting ADRs. Disseminating these findings to prescribers and clinicians will improve rational drug therapy and improve treatment outcomes in CKD patients.