The exact cause of schizophrenia, a severe neuropsychiatric illness, is still mostly unknown. Schizophrenia is a debilitating psychotic disorder. While many different factors have been linked to the onset of schizophrenia, the primary cause of the condition is still unknown. Psychosocial stress is one of the main environmental factors linked to schizophrenia, and it has been reported that these factors play roles in the pathogenesis of the disorder. Numerous researches have hypothesized that stressful life experiences and the continual social stress that comes with living in a city may cause schizophrenia to develop. Debilitating symptoms of both positive and negative symptoms affecting emotions and cognition can be seen in schizophrenia. Positive symptoms of schizophrenia include delusions, hallucinations, and disorderly speech and behavior. Negative symptoms include affective flattening and lack of motivation. Specific regulation from molecular signaling pathways is necessary for the development of the neural systems underpinning the social, cognitive, and emotional domains. Engaging in stimulating activities such as painting, drawing, dancing, and other art-related pursuits not only stimulates brain activity but also plays a role in promoting mental wellness. Additionally, participating in sports and physical activities contributes to increased blood flow to the brain, potentially reducing the risk of developing long-term mental health issues like schizophrenia. Better symptom management, an improvement in quality of life, an improvement in relapse rates, better treatment adherence, and long-term benefits are anticipated from the use of holistic approaches in the management of patients with schizophrenia.