Respiratory disorders impose a significant burden on individuals’ health and well-being globally. Herbal formulations have gained attention for their potential in managing such conditions. This single-arm clinical study aimed to evaluate the efficacy of Pankajakasthuri Breathe Eazy Excel Powder in managing various respiratory disorders. A total of 200 participants diagnosed with respiratory disorders, including asthma, chronic bronchitis, and allergic rhinitis, were enrolled in the study. Participants were administered Pankajakasthuri Breathe Eazy Excel Powder according to the recommended dosage for a duration of 6 months. Primary outcomes included improvements in respiratory symptoms, lung function parameters, and quality of life scores, assessed through standardized tools. Secondary outcomes comprised safety profiles and adverse events associated with the intervention. Statistical analyses were conducted to assess the significance of changes observed pre- and post-intervention. The results demonstrated statistically significant improvements in respiratory symptoms, lung function parameters, and quality of life scores following the administration of Pankajakasthuri Breathe Eazy Excel Powder. Moreover, the intervention exhibited a favorable safety profile with minimal adverse events reported. These findings suggest that Pankajakasthuri Breathe Eazy Excel Powder holds promise as an effective and safe adjunctive therapy for managing various respiratory disorders. Further randomized controlled trials with larger sample sizes are warranted to corroborate these findings and establish the clinical utility of this herbal formulation.