1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   Response - Informed Consent Form
   Response - Clinical Study Report
   
   
3. Who will be able to view these files?
   Response - Researchers whose proposed use of the data has been approved by an independent review committee identified for this purpose.
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response (Others) -  data will be available only if published in peer reviewed journal.


6. For how long will this data be available start date provided 01-01-2026 and end date provided 01-01-2027?
   Response - Immediately following publication. No end date.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

Osteoarthritis is a very common joint disease characterized by destruction of joint cartilage. It is produced by mechanical stress over the joint and it manifests as swelling, stiffness and joint pain.  Osteoarthritis of knee is a leading cause of chronic disability in elderly, prevalence of knee osteoarthritis rises with age and is more in females than in males. The knee joint is most complex and largest joint of the body and is most vulnerable to damage because it is a mobile and weight-bearing joint. Knee osteoarthritis is one of most common form of arthritis in synovial joints. Synovial membrane inflammation plays an important role in development of pain, joint inflammation and cartilage destruction. Hence, pro-inflammatory mediators also play an important role in osteoarthritis. Knee osteoarthritis can be co-related with Janu Sandhigatavata because it resembles in sign and symptoms of Sandhigatavata told in Ayurveda literature such as Sandhi Shula and  Shoth  in affected joints. In contemporary science a wide range of treatment modalities are available such as anti-inflammatory, analgesics, calcium and vitamin D supplements, steroids and physiotherapy but have limited prognosis due to side effects after prolonged use. So, there is need of more treatment modalities to manage sign and symptoms of knee osteoarthritis. Ayurveda offers various treatments for Sandhigatavata. There is no lasting treatment available for knee osteoarthritis and Acharya Caraka mentioned that if the disease is not treatable with all the treatment methods explained for that disease, then we should treat it as Raktaj Vyadhi. Acharya Charaka described Raktamokshana in Raktaj Vyadhi. Acharya Sushruta mentioned Siravedha in Vatavedan. Siravedha is an important surgical intervention in shalya tantra, Acharya Sushruta described   alone Siravedha as  Chikitsa-Ardha half treatment   in Shalya Tantra. Ayurveda emphasizes evaluation of patients in totality for perfect diagnosis and management of disease.  Acharya Caraka and Acharya Sushruta recommended extensive guidelines for assessment of disease and diseased. Prakriti assessment is a part of Dashavidha Pariksha. Prakriti is the nature of the body in terms of the Dosha and is decided at the time of conception according to the predominance of Dosha.  Prakriti of patients also plays an important role in deciding treatment modalities. This study is specially planned to see effect of Siravedha on knee osteoarthritis and to see change in inflammatory markers in blood after  Siravedha.